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One potential mechanism that could account for estrogen effects on the intestine is through its alterations in TJ and adhesion molecules which would alter intestinal permeability [94]

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The exact structure of BSEP is not known (Wakabayashi et al., 2004) but it is believed that BSEP contains two trans-membrane domains composed of six helices connected between the cytoplasmic domain that is homologous to the structure of p-glycoprotein (van Den Elsen et al., 1999)

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